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Article

Studies of the symmetric binding mode of daclatasvir and analogs using a new homology model of HCV NS5A GT-4a.

Journal of molecular modeling - 29 Dec 2022

Saad Kholoud A, Eldawy Mohammed A, Elokely Khaled M

Abstract excerpt

CONTEXT: Egypt has a high prevalence of the hepatitis C virus (HCV) genotype 4a (GT-4a). Unfortunately, the high resistance it exhibited still was not given the deserved attention in the scientific community. There is currently no consensus on the NS5A binding site because the crystal structure of HCV NS5A has not been resolved. The prediction of the binding modes of direct-acting antivirals (DAA) with the NS5A...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36580076
DOI: 10.1007/s00894-022-05420-4
PMCID: PMC9800351

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