Article
Circular permutation of chicken interleukin-1 beta enhances its thermostability.
Chemical communications (Cambridge, England) - 25 Apr 2014
Chen Wen-Ting, Chen Ting, Cheng Chao-Sheng, Huang Wen-Yang, Wang Xinquan, Yin Hsien-Sheng
Abstract excerpt
Interleukin-1β is a cytokine critically involved in immune and inflammatory responses. To extend its use as a component of avian vaccines, a circularly permuted chicken interleukin-1β was synthesized that maintains its activity after pre-incubation at high temperatures, unlike wild-type chicken interleukin-1β, which is irreversibly inactivated at high temperatures.
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