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Article

Immunogenicity of a Yersinia pestis vaccine antigen monomerized by circular permutation.

Infection and immunity - 1 Dec 2006

Chalton David A, Musson Julie A, Flick-Smith Helen, Walker Nicola, McGregor Alistair, Lamb Heather K, Williamson E Diane, Miller Julie, Robinson John H, Lakey Jeremy H

Abstract excerpt

Caf1, a chaperone-usher protein from Yersinia pestis, is a major protective antigen in the development of subunit vaccines against plague. However, recombinant Caf1 forms polymers of indeterminate size. We report the conversion of Caf1 from a polymer to a monomer by circular permutation of the gene. Biophysical evaluation confirmed that the engineered Caf1 was a folded monomer. We compared the immunogenicity of...

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Identifiers

PMID: 16982834
DOI: 10.1128/IAI.00437-06
PMCID: PMC1698084

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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