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Article

Medium-high resolution electrochemical genotyping of HLA-DQ2/DQ8 for detection of predisposition to coeliac disease.

Analytical and bioanalytical chemistry - 1 May 2014

Joda Hamdi, Beni Valerio, Alakulppi Noora, Partanen Jukka, Lind Kristina, Strömbom Linda, Latta Daniel, Höth Julian, Katakis Ioanis, O'Sullivan Ciara K

Abstract excerpt

Coeliac disease is a small intestinal disorder, induced by ingestion of gluten in genetically predisposed individuals. Coeliac disease has been strongly linked to human leukocyte antigens (HLA) located on chromosome 6, with almost 100 % of coeliac disease sufferers carrying either a HLA-DQ2 or HLA-DQ8 heterodimer, with the majority carrying HLA-DQ2 encoded by the DQA1*05:01/05:05, DQB1*02:01/02:02 alleles,...

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PMID: 24633503
DOI: 10.1007/s00216-014-7650-x

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