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Article

Gold nanoparticle fluorescent molecular beacon for low-resolution DQ2 gene HLA typing.

Analytical and bioanalytical chemistry - 1 Jan 2012

Beni Valerio, Zewdu Taye, Joda Hamdi, Katakis Ioanis, O'Sullivan Ciara K

Abstract excerpt

Coeliac disease is an inflammation of the small intestine triggered by gluten ingestion. We present a fluorescent genosensor, exploiting molecular-beacon-functionalized gold nanoparticles, for the identification of human leukocyte antigen (HLA) DQ2 gene, a key genetic factor in coeliac disease. Optimization of sensor performance was achieved by tuning the composition of the oligonucleotide monolayer immobilized...

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PMID: 22086396
DOI: 10.1007/s00216-011-5493-2

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