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Article

Common variants of the PINK1 and PARL genes do not confer genetic susceptibility to schizophrenia in Han Chinese.

Molecular genetics and genomics : MGG - 1 Apr 2015

Li Xiao, Zhang Wen, Zhang Chen, Yi Zhenghui, Zhang Deng-Feng, Gong Wei, Tang Jinsong, Wang Dong, Lu Weihong, Chen Xiaogang, Fang Yiru, Yao Yong-Gang

Abstract excerpt

Schizophrenia is a prevalent psychiatric disorder with a complex etiology. Mitochondrial dysfunction has been frequently reported in schizophrenia. Phosphatase and tension homologue-induced kinase 1 (PINK1) and presenilin-associated rhomboid-like protease (PARL) are mitochondrial proteins, and genetic variants of these two genes may confer genetic susceptibility to schizophrenia by influencing mitochondrial...

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Identifiers

PMID: 25354644
DOI: 10.1007/s00438-014-0942-1

Genes

PINK1
PARL
KIF17
PGC

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