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Article

Nanotopography Directs Mesenchymal Stem Cells to Osteoblast Lineage Through Regulation of microRNA‐SMAD‐BMP‐2 Circuit

12 Mar 2014

Abstract excerpt

The aim of this study was to investigate if chemically produced nanotopography on titanium (Ti) surface induces osteoblast differentiation of cultured human bone marrow mesenchymal stem cells (hMSCs) by regulating the expression of microRNAs (miRs). It was demonstrated that Ti with nanotopography induces osteoblast differentiation of hMSCs as evidenced by upregulation of osteoblast specific markers compared with...

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PMID: 24619927
DOI: 10.1002/jcp.24614

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