Article
Genetic polymorphism rs6922269 in the MTHFD1L gene is associated with survival and baseline active vitamin B12 levels in post-acute coronary syndromes patients.
PloS one - 1 Jan 2014
Palmer Barry R, Slow Sandy, Ellis Katrina L, Pilbrow Anna P, Skelton Lorraine, Frampton Chris M, Palmer Suetonia C, Troughton Richard W, Yandle Tim G, Doughty Rob N, Whalley Gillian A, Lever Michael, George Peter M, Chambers Stephen T, Ellis Chris, Richards A Mark, Cameron Vicky A
Abstract excerpt
BACKGROUND AND AIMS: The methylene-tetrahydrofolate dehydrogenase (NADP+ dependent) 1-like (MTHFD1L) gene is involved in mitochondrial tetrahydrofolate metabolism. Polymorphisms in MTHFD1L, including rs6922269, have been implicated in risk for coronary artery disease (CAD). We investigated the association between rs6922269 and known metabolic risk factors and survival in two independent cohorts of coronary heart...
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