Article
Allele frequencies of BRAFV600 mutations in primary melanomas and matched metastases and their relevance for BRAF inhibitor therapy in metastatic melanoma.
Oncotarget - 10 Nov 2015
Satzger Imke, Marks Lena, Kerick Martin, Klages Sven, Berking Carola, Herbst Rudolf, Völker Bernward, Schacht Vivien, Timmermann Bernd, Gutzmer Ralf
Abstract excerpt
BACKGROUND: The detection of BRAFV600 mutations in patients with metastatic melanoma is important because of the availability of BRAF inhibitor therapy. However, the clinical relevance of the frequency of BRAFV600 mutant alleles is unclear. PATIENTS AND METHODS: Allele frequencies of BRAFV600 mutations were analyzed by ultra-deep next-generation sequencing in formalin-fixed, paraffin-embedded melanoma tissue (75...
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