Article
Differential requirement for PBP1a and PBP1b in in vivo and in vitro fitness of Vibrio cholerae.
Infection and immunity - 1 May 2014
Dörr Tobias, Möll Andrea, Chao Michael C, Cava Felipe, Lam Hubert, Davis Brigid M, Waldor Matthew K
Abstract excerpt
We investigated the roles of the Vibrio cholerae high-molecular-weight bifunctional penicillin binding proteins, PBP1a and PBP1b, in the fitness of this enteric pathogen. Using a screen for synthetic lethality, we found that the V. cholerae PBP1a and PBP1b proteins, like their Escherichia coli homologues, are each essential in the absence of the other and in the absence of the other's putative activator, the...
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