Article
Discrete and overlapping functions of peptidoglycan synthases in growth, cell division and virulence of Listeria monocytogenes.
Molecular microbiology - 1 Jan 2015
Rismondo Jeanine, Möller Lars, Aldridge Christine, Gray Joe, Vollmer Waldemar, Halbedel Sven
Abstract excerpt
Upon ingestion of contaminated food, Listeria monocytogenes can cause serious infections in humans that are normally treated with β-lactam antibiotics. These target Listeria's five high molecular weight penicillin-binding proteins (HMW PBPs), which are required for peptidoglycan biosynthesis. The two bi-functional class A HMW PBPs PBP A1 and PBP A2 have transglycosylase and transpeptidase domains catalyzing...
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