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Article

Identification of the transforming <i>STRN-ALK</i> fusion as a potential therapeutic target in the aggressive forms of thyroid cancer

3 Feb 2014

Abstract excerpt

Thyroid cancer is a common endocrine malignancy that encompasses well-differentiated as well as dedifferentiated cancer types. The latter tumors have high mortality and lack effective therapies. Using a paired-end RNA-sequencing approach, we report the discovery of rearrangements involving the anaplastic lymphoma kinase (ALK) gene in thyroid cancer. The most common of these involves a fusion between ALK and the...

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PMID: 24613930
DOI: 10.1073/pnas.1321937111

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