Shedding of GPP130 by PC7 and Furin: Implication in Lung Cancer Progression

Abstract excerpt

From a previously performed proteomics screen, GPP130, or Golgi phosphoprotein of 130 kDa, was identified as a potential substrate of the proprotein convertase 7 (PC7; PCSK7). GPP130 is a type-II transmembrane protein with a luminal domain containing endosomal and Golgi-retrieval determinants, enabling a unique trafficking route. Most of the previous work on GPP130 relates to its binding and retrograde trafficking...

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• Autophagy in Disease and Therapy
• Cell Adhesion Molecules Research
• Cellular transport and secretion
• Endoplasmic Reticulum Stress and Disease
• Erythrocyte Function and Pathophysiology
• Glycosylation and Glycoproteins Research
• Pancreatic function and diabetes
• RNA modifications and cancer

Identifiers and source

Literature Corpus work

e3cb43ce-83cf-5053-963e-fc6bb5a77331

DOI

10.20944/preprints202411.0961.v1