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Article

Distinct profile of HIF1α, PTCH, EphB2, or DNA repair protein expression and BRAF mutation in colorectal serrated adenoma.

Journal of gastroenterology and hepatology - 1 Jun 2014

Morimoto Takashi, Mitomi Hiroyuki, Saito Tsuyoshi, Takahashi Michiko, Murakami Takashi, Sakamoto Naoto, Yao Takashi, Watanabe Sumio

Abstract excerpt

BACKGROUND AND AIMS: The serrated colorectal carcinoma (CRC) as proposed to arise from serrated adenoma (SA) is characterized by upregulation of HIF1α, suppression of PTCH or EphB2, loss of DNA repair proteins, and BRAF mutation. The aim of this study was to evaluate alterations of these candidat...

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Source

Identifiers

PMID: 24612059
DOI: 10.1111/jgh.12553

Genes

BRAF
MGMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24612059-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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