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Article

Age-related brain expression and regulation of the chemokine CCL4/MIP-1β in APP/PS1 double-transgenic mice.

Journal of neuropathology and experimental neurology - 1 Apr 2014

Zhu Min, Allard Joanne S, Zhang Yongqing, Perez Evelyn, Spangler Edward L, Becker Kevin G, Rapp Peter R

Abstract excerpt

The detrimental effect of activation of the chemokine CCL4/MIP-1β on neuronal integrity in patients with HIV-associated dementia has directed attention to the potential role of CCL4 expression and regulation in Alzheimer disease. Here, we show that CCL4 mRNA and protein are overexpressed in the brains of APPswe/PS1ΔE9 (APP/PS1) double-transgenic mice, a model of cerebral amyloid deposition; expression was minimal...

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Share to Aging
Share to Amyloid beta-Peptides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Amyloid beta-Protein Precursor

Share to Chemokine CCL4

Share to Chromatin Immunoprecipitation

Share to Enzyme-Linked Immunosorbent Assay

Share to Glial Fibrillary Acidic Protein

Share to Presenilin-1

Source

Open in PubMed Open full text

Identifiers

PMID: 24607962
DOI: 10.1097/NEN.0000000000000060
PMCID: PMC3977177

Genes

CCL4
APP
ATF3
MIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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