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Article

Final pre-40S maturation depends on the functional integrity of the 60S subunit ribosomal protein L3.

PLoS genetics - 1 Mar 2014

García-Gómez Juan J, Fernández-Pevida Antonio, Lebaron Simon, Rosado Iván V, Tollervey David, Kressler Dieter, de la Cruz Jesús

Abstract excerpt

Ribosomal protein L3 is an evolutionarily conserved protein that participates in the assembly of early pre-60S particles. We report that the rpl3[W255C] allele, which affects the affinity and function of translation elongation factors, impairs cytoplasmic maturation of 20S pre-rRNA. This was not seen for other mutations in or depletion of L3 or other 60S ribosomal proteins. Surprisingly, pre-40S particles...

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Identifiers

PMID: 24603549
DOI: 10.1371/journal.pgen.1004205
PMCID: PMC3945201

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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