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Article

miR-21 promotes human nucleus pulposus cell proliferation through PTEN/AKT signaling.

International journal of molecular sciences - 5 Mar 2014

Liu Hongzhe, Huang Xiangwang, Liu Xiangyang, Xiao Sheng, Zhang Yi, Xiang Tiecheng, Shen Xiongjie, Wang Guoping, Sheng Bin

Abstract excerpt

The precise role of nucleus pulposus cell proliferation in the pathogenesis of intervertebral disc degeneration remains to be elucidated. Recent findings have revealed that microRNAs, a class of small noncoding RNAs, may regulate cell proliferation in many pathological conditions. Here, we showed that miR-21 was significantly upregulated in degenerative nucleus pulposus tissues when compared with nucleus pulposus...

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Identifiers

PMID: 24603539
DOI: 10.3390/ijms15034007
PMCID: PMC3975380

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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