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Article

Pseudogenization of testis-specific Lfg5 predates human/Neanderthal divergence.

Journal of human genetics - 1 May 2014

Mariotti Marco, Smith Temple F, Sudmant Peter H, Goldberger Gabriel

Abstract excerpt

Recent reviews discussed the critical roles of apoptosis in human spermatogenesis and infertility. These reviews highlight the FasL-induced caspase cascade in apoptosis lending importance to our discovery of the pseudogene status of the Lfg5 gene in modern humans, Neanderthal and the Denisovan. This gene is a member of the ancient and highly conserved apoptosis Lifeguard family. This pseudogenization is the...

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PMID: 24599118
DOI: 10.1038/jhg.2014.6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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