Two patients with intestinal failure requiring home parenteral nutrition, a NOD2 mutation and tuberculous lymphadenitis.

doi:10.1186/1471-230X-14-43

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Two patients with intestinal failure requiring home parenteral nutrition, a NOD2 mutation and tuberculous lymphadenitis.

BMC gastroenterology - 6 Mar 2014

Schäffler Holger, Teufel Matthias, Fleischer Sabrina, Hsieh Chih-Jen, Frick Julia-Stefanie, Lamprecht Georg

Abstract excerpt

BACKGROUND: Mutations in the NOD2 gene are a significant risk factor to acquire intestinal failure requiring home parenteral nutrition. Tuberculous lymphadenitis is the main manifestation of extrapulmonary tuberculosis. Defects in the innate immunity, including NOD2 mutations, may increase the risk for acquiring infections caused by M. tuberculosis. An association of intestinal failure, mutations in the NOD2 gene...

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