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Article

Increased drug resistance is associated with reduced glucose levels and an enhanced glycolysis phenotype.

British journal of pharmacology - 1 Jul 2014

Bhattacharya B, Low S H H, Soh C, Kamal Mustapa N, Beloueche-Babari M, Koh K X, Loh J, Soong R

Abstract excerpt

BACKGROUND AND PURPOSE: The testing of anticancer compounds in vitro is usually performed in hyperglycaemic cell cultures, although many tumours and their in vivo microenvironments are hypoglycaemic. Here, we have assessed, in cultures of tumour cells, the effects of reduced glucose levels on resistance to anticancer drugs and investigated the underlying cellular mechanisms. EXPERIMENTAL APPROACH: PIK3CA mutant...

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Identifiers

PMID: 24597478
DOI: 10.1111/bph.12668
PMCID: PMC4080979

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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