Article
Inhibition of PI3K suppresses propagation of drug-tolerant cancer cell subpopulations enriched by 5-fluorouracil.
Scientific reports - 23 May 2017
Ishida Kaoru, Ito Chie, Ohmori Yukimi, Kume Kohei, Sato Kei A, Koizumi Yuka, Konta Akari, Iwaya Takeshi, Nukatsuka Mamoru, Kobunai Takashi, Takechi Teiji, Nishizuka Satoshi S
Abstract excerpt
Drug-tolerant cancer cell subpopulations are responsible for relapse after chemotherapy. By continuously exposing the gastric cancer cell line MKN45 to 5-FU for >100 passages, we established a 5-fluorouracil (5-FU)-tolerant line, MKN45/5FU. Orthotopic xenografts of MKN45/5FU cells in the stomach of nude mice revealed that these cells had a high potential to metastasize to sites such as the liver. Levels of...
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