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Article

Genetic variation in genes encoding airway epithelial potassium channels is associated with chronic rhinosinusitis in a pediatric population.

PloS one - 1 Jan 2014

Purkey Michael T, Li Jin, Mentch Frank, Grant Struan F A, Desrosiers Martin, Hakonarson Hakon, Toskala Elina

Abstract excerpt

BACKGROUND: Apical potassium channels regulate ion transport in airway epithelial cells and influence air surface liquid (ASL) hydration and mucociliary clearance (MCC). We sought to identify whether genetic variation within genes encoding airway potassium channels is associated with chronic rhinosinusitis (CRS). METHODS: Single nucleotide polymorphism (SNP) genotypes for selected potassium channels were derived...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 24595210
DOI: 10.1371/journal.pone.0089329
PMCID: PMC3940609

Genes

KCNMA1
KCNQ5
ASL
MCC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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