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Article

BRAF-V600 mutations have no prognostic impact in stage IV melanoma patients treated with monochemotherapy.

PloS one - 1 Jan 2014

Meckbach Diana, Keim Ulrike, Richter Sabina, Leiter Ulrike, Eigentler Thomas K, Bauer Jürgen, Pflugfelder Annette, Büttner Petra, Garbe Claus, Weide Benjamin

Abstract excerpt

BACKGROUND: The impact of BRAF tumor mutations on the natural course of disease of melanoma patients is controversial. PATIENTS AND METHODS: We analyzed the mutational status and overall survival of 215 patients receiving treatment with dacarbazine or temozolomide. All patients who started first-line treatment at our institution between 2000 and 2010 were included to prevent selection and bias due to thereafter...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 24586605
DOI: 10.1371/journal.pone.0089218
PMCID: PMC3930670

Genes

BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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