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Article

The impact of intra-clonal heterogeneity on the treatment of multiple myeloma.

British journal of haematology - 1 May 2014

Brioli Annamaria, Melchor Lorenzo, Cavo Michele, Morgan Gareth J

Abstract excerpt

It is clear that cancers comprise a mixture of clones, a feature termed intra-clonal heterogeneity, that compete for spatial and nutritional resources in a fashion that leads to disease progression and therapy resistance. This process of competition resembles the schema proposed by Darwin to explain the origin of the species, and applying these evolutionary biology concepts to cancer has the potential to improve...

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Identifiers

PMID: 24580032
DOI: 10.1111/bjh.12805

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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