Genome-wide genotyping demonstrates a polygenic risk score associated with white matter hyperintensity volume in CADASIL.

doi:10.1161/STROKEAHA.113.004461

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Genome-wide genotyping demonstrates a polygenic risk score associated with white matter hyperintensity volume in CADASIL.

Stroke - 1 Apr 2014

Opherk Christian, Gonik Mariya, Duering Marco, Malik Rainer, Jouvent Eric, Hervé Dominique, Adib-Samii Poneh, Bevan Steve, Pianese Luigi, Silvestri Serena, Dotti Maria Teresa, De Stefano Nicola, Liem Michael, Boon Elles M J, Pescini Francesca, Pachai Chahin, Bracoud Luc, Müller-Myhsok Bertram, Meitinger Thomas, Rost Natalia, Pantoni Leonardo, Lesnik Oberstein Saskia, Federico Antonio, Ragno Michele, Markus Hugh S, Tournier-Lasserve Elisabeth, Rosand Jonathan, Chabriat Hugues, Dichgans Martin

Abstract excerpt

BACKGROUND AND PURPOSE: White matter hyperintensities (WMH) on MRI are a quantitative marker for sporadic cerebral small vessel disease and are highly heritable. To date, large-scale genetic studies have identified only a single locus influencing WMH burden. This might in part relate to biological heterogeneity of sporadic WMH. The current study searched for genetic modifiers of WMH volume in cerebral...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CADASIL

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Hypertension

Share to Leukoencephalopathies

Share to Magnetic Resonance Imaging

Share to Models, Genetic

Share to Quantitative Trait Loci

Share to Risk Factors

Source

Open in PubMed

Identifiers

PMID: 24578207
DOI: 10.1161/STROKEAHA.113.004461

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome-wide genotyping demonstrates a polygenic risk score associated with white matter hyperintensity volume in CADASIL.PMID 24578207Read ↗

Heritability of MRI Lesion Volume in CADASILSemantic proximity Read ↗

APOE ɛ2 is associated with white matter hyperintensity volume in CADASIL.Semantic proximity Read ↗

The Genetics of White Matter LesionsSemantic proximity Read ↗

Genotype-phenotype correlations in a Scottish CADASIL cohort and comparison with sporadic small vessel disease.Semantic proximity Read ↗

Monogenic causes of cerebral small vessel disease and stroke.Semantic proximity Read ↗

Cerebral small vessel disease genomics and its implications across the lifespanSemantic proximity Read ↗

Genetic Study of White Matter Integrity in UK Biobank (N=8448) and the Overlap With Stroke, Depression, and DementiaSemantic proximity Read ↗

Genome-wide meta-analysis of cerebral white matter hyperintensities in patients with stroke.Semantic proximity Read ↗

New information on the genetics of stroke.Semantic proximity Read ↗

The genetic architecture of intracerebral hemorrhage.Semantic proximity Read ↗

Whole Exome Sequencing of Suspected Monogenic Cerebral Small Vessel Disease Patients reveals Novel Gene AssociationsSemantic proximity Read ↗

Deep resequencing of the 1q22 locus in non-lobar intracerebral hemorrhageSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.