Article
Carboxyl terminus of Hsp70-interacting protein regulation of osteoclast formation in mice through promotion of tumor necrosis factor receptor-associated factor 6 protein degradation.
Arthritis & rheumatology (Hoboken, N.J.) - 1 Jul 2014
Li Shan, Shu Bing, Zhang Yanquan, Li Jia, Guo Junwei, Wang Yinyin, Ren Fangli, Xiao Guozhi, Chang Zhijie, Chen Di
Abstract excerpt
OBJECTIVE: Carboxyl terminus of Hsp70-interacting protein (CHIP or STUB1) is an E3 ligase that regulates the stability of several proteins involved in tumor growth and metastasis. However, the role of CHIP in bone growth and bone remodeling in vivo has not been reported. This study was undertaken to investigate the role and mechanism of CHIP in regulation of bone mass and bone remodeling. METHODS: The bone...
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