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Article

Dynamic Hedgehog signalling pathway activity in germline stem cells

24 Feb 2014

Abstract excerpt

Although the contribution of Hedgehog (Hh) signalling to stem cell development and oncogenesis is well recognised, its importance for spermatogonial stem cells (SSCs) has not been established. Here we interrogate adult rat SSCs using an established model in which only undifferentiated spermatogonial cells remain in the testis at 15 weeks following irradiation, and spermatogonial differentiation is induced within...

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PMID: 24574096
DOI: 10.1111/j.2047-2927.2014.00187.x

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