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Article

Smoothened mediates medaka spermatogonia proliferation via Gli1–Rgcc–Cdk1 axis

8 Aug 2023

Abstract excerpt

The proliferation of spermatogonia directly affects spermatogenesis and male fertility, but its underlying molecular mechanisms are poorly understood. In this study, Smoothened (Smo), the central transducer of Hedgehog signaling pathway, was characterized in medaka (Oryzias latipes), and its role and underlying mechanisms in the proliferation of spermatogonia were investigated. Smo was highly expressed in...

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Share to Epigenetics and DNA Methylation
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PMID: 37552059
DOI: 10.1093/biolre/ioad090

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