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Article

Role of the Hedgehog Signaling Pathway in Regulating the Behavior of Germline Stem Cells

1 Jan 2017

Abstract excerpt

Germline stem cells (GSCs) are adult stem cells that are responsible for the production of gametes and include spermatogonial stem cells (SSCs) and ovarian germline stem cells (OGSCs). GSCs are located in a specialized microenvironment in the gonads called the niche. Many recent studies have demonstrated that multiple signals in the niche jointly regulate the proliferation and differentiation of GSCs, which is of...

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PMID: 28883837
DOI: 10.1155/2017/5714608

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