Article
N-glycomic profiling of a glucosidase II mutant of Dictyostelium discoideum by ''off-line'' liquid chromatography and mass spectrometry.
Electrophoresis - 1 Aug 2014
Hykollari Alba, Dragosits Martin, Rendić Dubravko, Wilson Iain B H, Paschinger Katharina
Abstract excerpt
In this study, we have performed the first mass spectrometric analysis of N-glycans of the M31 mutant strain of the cellular slime mould Dictyostelium discoideum, previously shown to have a defect in glucosidase II. Together with glucosidase I, this enzyme mediates part of the initial processing of N-glycans; defects in either glucosidase are associated with human diseases and result in an accumulation of...
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