Article
Toxoplasma gondii infection of decidual CD1c(+) dendritic cells enhances cytotoxicity of decidual natural killer cells.
Inflammation - 1 Aug 2014
Liu Xianbing, Zhao Mingdong, Yang Xin, Han Meiyu, Xu Xiaoyan, Jiang Yuzhu, Hu Xuemei
Abstract excerpt
There is crosstalk between decidual natural killer (dNK) cells and decidual dendritic cells (dDCs) that promotes tolerance of trophoblast cells carrying paternally derived antigens. In the present study, we report that infection of CD1c(+) dDCs with Toxoplasma gondii enhanced gamma interferon (IFN-γ) production by dNK cells in co-culture. The enhancement of IFN-γ production was induced by cytokine IL-12 which...
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