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Article

Decidualization-derived cAMP promotes decidual NK cells to be angiogenic phenotype.

American journal of reproductive immunology (New York, N.Y. : 1989) - 1 Sept 2022

Jin Xueling, Mao Lie, Zhao Weijie, Liu Lu, Li Yanhong, Li Dajin, Zhang Ying, Du Meirong

Abstract excerpt

BACKGROUND: During early pregnancy, a large number of CD56bright natural killer cells (NKs) are accumulated in the decidua; unlike peripheral and cord blood NK cells (pNK and cNK), these decidual NK cells (dNK) display a great capacity to secrete a series of angiogenic/vascular factors, which are essential for placental development. However, the mechanism underlying the formation of dNK cells with an angiogenic...

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PMID: 35348271
DOI: 10.1111/aji.13540

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