Article
Novel and functional ABCB1 gene variant in sporadic Parkinson's disease.
Neuroscience letters - 30 Apr 2014
Li Yuequn, Li Yonghua, Pang Shuchao, Huang Wenhui, Zhang Aimei, Hawley Robert G, Yan Bo
Abstract excerpt
Parkinson's disease (PD) is a common progressive neurodegenerative disease. Most cases of PD are sporadic, which is caused by interaction of genetic and environmental factors. To date, genetic causes for sporadic PD remain largely unknown. ATP-binding cassette sub-family B member 1 (ABCB1) is a membrane-associated protein that acts as an efflux transporter for many substrates, including chemotherapeutic agents,...
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