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Article

Overlap between Parkinson disease and Alzheimer disease in ABCA7 functional variants

15 Jan 2016

Abstract excerpt

OBJECTIVE: Given their reported function in phagocytosis and clearance of protein aggregates in Alzheimer disease (AD), we hypothesized that variants in ATP-binding cassette transporter A7 (ABCA7) might be involved in Parkinson disease (PD). METHODS: ABCA7 variants were identified using whole-exome sequencing (WES) on 396 unrelated patients with PD and 222 healthy controls. In addition, we used the publicly...

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PMID: 27066581
DOI: 10.1212/nxg.0000000000000044

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