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Article

First look at the effect of overexpression of TIGR/MYOC on the transcriptome of the human trabecular meshwork.

Experimental eye research - 1 Jun 2006

Borrás Teresa, Bryant Paul A, Chisolm Sarah S

Abstract excerpt

Wild-type TIGR/MYOC is a secreted protein implicated in the development of steroid glaucoma. Mutations in TIGR/MYOC have been linked to some patients who develop elevated intraocular pressure (IOP) and glaucoma. Because there is evidence of some other factors contributing to the TIGR/MYOC causative role in glaucoma, and because substantial increased levels of a particular cellular mRNA and protein might alter...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16476427
DOI: 10.1016/j.exer.2005.11.005

Genes

MYOC
MMP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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