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Menin Is Required for Optimal Processing of the MicroRNA let-7a

22 Feb 2014

Abstract excerpt

Multiple endocrine neoplasia type I (MEN1) is an inherited syndrome that includes susceptibility to pancreatic islet hyperplasia. This syndrome results from mutations in the MEN1 gene, which encodes menin protein. Menin interacts with several transcription factors, including JunD, and inhibits their activities. However, the precise mechanism by which menin suppresses gene expression is not well understood. Here,...

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PMID: 24563463
DOI: 10.1074/jbc.m113.520692

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