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Article

A novel pathway links oxidative stress to loss of insulin growth factor-2 (IGF2) imprinting through NF-κB activation.

PloS one - 1 Jan 2014

Yang Bing, Wagner Jennifer, Damaschke Nathan, Yao Tianyu, Wuerzberger-Davis Shelly M, Lee Moon-Hee, Svaren John, Miyamoto Shigeki, Jarrard David F

Abstract excerpt

Genomic imprinting is the allele-specific expression of a gene based on parental origin. Loss of imprinting(LOI) of Insulin-like Growth Factor 2 (IGF2) during aging is important in tumorigenesis, yet the regulatory mechanisms driving this event are largely unknown. In this study oxidative stress,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24558376
DOI: 10.1371/journal.pone.0088052
PMCID: PMC3928145

Genes

IGF2
CTCF
HDAC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24558376-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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