Article
A novel pathway links oxidative stress to loss of insulin growth factor-2 (IGF2) imprinting through NF-κB activation.
PloS one - 1 Jan 2014
Yang Bing, Wagner Jennifer, Damaschke Nathan, Yao Tianyu, Wuerzberger-Davis Shelly M, Lee Moon-Hee, Svaren John, Miyamoto Shigeki, Jarrard David F
Abstract excerpt
Genomic imprinting is the allele-specific expression of a gene based on parental origin. Loss of imprinting(LOI) of Insulin-like Growth Factor 2 (IGF2) during aging is important in tumorigenesis, yet the regulatory mechanisms driving this event are largely unknown. In this study oxidative stress, measured by increased NF-κB activity, induces LOI in both cancerous and noncancerous human prostate cells. Decreased...
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