Article
A novel mutation of Hyaluronan synthase 2 gene in Chinese children with ventricular septal defect.
PloS one - 1 Jan 2014
Zhu Xiaomei, Deng Xiaopeng, Huang Guangying, Wang Jing, Yang Jingwen, Chen Si, Ma Xu, Wang Binbin
Abstract excerpt
As a major product of extracellular matrix (ECM), Hyaluronic acid (HA) is involved in early cardiac development and mainly synthesized by Hyaluronan synthase 2 (HAS2) during embryogenesis. Targeted deletion of HAS2 gene in mice led to obvious cardiac and vascular defects. To clarify the potential association of the mutation in HAS2 with the development of congenital heart disease (CHD), in this study, we...
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