Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Systems Biology Approach Identifies Effective Tumor–Stroma Common Targets for Oral Squamous Cell Carcinoma

20 Feb 2014

Abstract excerpt

The complex interactions between cancer cells and their surrounding stromal microenvironment play important roles in tumor initiation and progression and represent viable targets for therapeutic intervention. Here, we propose a concept of common target perturbation (CTP). CTP acts simultaneously on the same target in both the tumor and its stroma that generates a bilateral disruption for potentially improved...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Cancer Genomics and Diagnostics
Share to Cancer, Hypoxia, and Metabolism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24556718
DOI: 10.1158/0008-5472.can-13-2275

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Systems Biology Approach Identifies Effective Tumor–Stroma Common Targets for Oral Squamous Cell CarcinomaPMID 24556718Read ↗

GITR and TIGIT immunotherapy provokes divergent multi-cellular responses in the tumor microenvironment of gastrointestinal cancersSemantic proximity Read ↗

Systematic Identification of Druggable Epithelial–Stromal Crosstalk Signaling Networks in Ovarian CancerSemantic proximity Read ↗

In silico identification of potential therapeutic targets in the TGF-β signal transduction pathway.Semantic proximity Read ↗

Cancerous perturbations within the ERK, PI3K/Akt, and Wnt/β-catenin signaling network constitutively activate inter-pathway positive feedback loops.Semantic proximity Read ↗

Engineering Cancer Antigen-Specific T Cells to Overcome the Immunosuppressive Effects of TGF-βSemantic proximity Read ↗

A novel TGF-β receptor II mutation (I227T/N236D) promotes aggressive phenotype of oral squamous cell carcinoma via enhanced EGFR signaling.Semantic proximity Read ↗

Combinatorial interventions inhibit TGFβ-driven epithelial-to-mesenchymal transition and support hybrid cellular phenotypesSemantic proximity Read ↗

Exploiting polypharmacology for drug target deconvolution.Semantic proximity Read ↗

A novel gain-of-function mutation of TGF-β receptor II promotes cancer progression via delayed receptor internalization in oral squamous cell carcinoma.Semantic proximity Read ↗

A molecular systems architecture of the mesenchymal stromal cell microenvironmentSemantic proximity Read ↗

Benefits of Multifaceted Chemopreventives in the Suppression of the Oral Squamous Cell Carcinoma (OSCC) Tumorigenic Phenotype.Semantic proximity Read ↗

Discovery of Drug Synergies in Gastric Cancer Cells Predicted by Logical ModelingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.