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Article

Inactivation of SMC2 shows a synergistic lethal response in<i>MYCN</i>-amplified neuroblastoma cells

7 Feb 2014

Abstract excerpt

The condensin complex is required for chromosome condensation during mitosis; however, the role of this complex during interphase is unclear. Neuroblastoma is the most common extracranial solid tumor of childhood, and it is often lethal. In human neuroblastoma, MYCN gene amplification is correlated with poor prognosis. This study demonstrates that the gene encoding the condensin complex subunit SMC2 is...

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PMID: 24553121
DOI: 10.4161/cc.27983

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