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MicroRNA-151 and Its Hosting Gene FAK (Focal Adhesion Kinase) Regulate Tumor Cell Migration and Spreading of Hepatocellular Carcinoma†

1 Sept 2010

Abstract excerpt

Recurrent chromosomal aberrations are often observed in hepatocellular carcinoma (HCC), but little is known about the functional non-coding sequences, particularly microRNAs (miRNAs), at the chromosomal breakpoints in HCC. Here we show that 22 miRNAs are often amplified or deleted in HCC. MicroRNA-151 (miR-151), a frequently amplified miRNA on 8q24.3, is correlated with intrahepatic metastasis of HCC. We further...

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PMID: 20812359
DOI: 10.1002/hep.23854

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