Article

IGF1/IGF1R signaling promotes the expansion of liver CSCs and serves as a potential therapeutic target in HCC

2025-05-20

Abstract excerpt

<title>Abstract</title> <p>The presence of cancer stem cells (CSCs) play important roles in hepatocellular carcinoma (HCC) relapse, metastasis, drug resistance. The IGF1/IGF-1R signaling pathway has been implicated in the development and progression of various cancers, and plays an important role in maintaining the stemness of various types of CSCs, but its role in liver CSCs remains unclear. Here, we report that...

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Literature Corpus work: 205297fc-984a-5f4c-a2a2-785f1bb9130b
DOI: 10.21203/rs.3.rs-6376546/v1

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