Article
Identification of an LGP2-associated MDA5 agonist in picornavirus-infected cells.
eLife - 18 Feb 2014
Deddouche Safia, Goubau Delphine, Rehwinkel Jan, Chakravarty Probir, Begum Sharmin, Maillard Pierre V, Borg Annabel, Matthews Nik, Feng Qian, van Kuppeveld Frank J M, Reis e Sousa Caetano
Abstract excerpt
The RIG-I-like receptors RIG-I, LGP2, and MDA5 initiate an antiviral response that includes production of type I interferons (IFNs). The nature of the RNAs that trigger MDA5 activation in infected cells remains unclear. Here, we purify and characterise LGP2/RNA complexes from cells infected with encephalomyocarditis virus (EMCV), a picornavirus detected by MDA5 and LGP2 but not RIG-I. We show that those complexes...
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