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Article

Innate Immune Detection of Cardioviruses and Viral Disruption of Interferon Signaling

12 Oct 2018

Abstract excerpt

Cardioviruses are members of the Picornaviridae family and infect a variety of mammals, from mice to humans. Replication of cardioviruses produces double stranded RNA that is detected by helicases in the RIG-I-like receptor family and leads to a signaling cascade to produce type I interferon. Like other viruses within Picornaviridae, however, cardioviruses have evolved several mechanisms to inhibit interferon...

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PMID: 30369921
DOI: 10.3389/fmicb.2018.02448

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