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Article

Identification and functional analysis of common sequence variants in the DFNA15 gene, Brn-3c.

Gene - 1 Oct 2007

Nolan Lisa S, Jagutpal Sanjay S, Cadge Barbara A, Woo Patricia, Dawson Sally J

Abstract excerpt

A rare mutation in Brn-3c (Brn3.1, POU4F3) underlies adult onset hearing loss (DFNA15) and targeted deletion of this gene in mice leads to complete deafness due to loss of sensory hair cells from the cochlea. Therefore the aim of our study was to identify and characterise common functional variation in the Brn-3c gene, which could potentially be a genetic risk for more common forms of adult onset hearing loss. We...

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Identifiers

PMID: 17611044
DOI: 10.1016/j.gene.2007.05.023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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