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Article

First evidence of a polygenic susceptibility to pain in a pediatric cohort.

Anesthesia and analgesia - 1 Jan 2013

Mamie Chantal, Rebsamen Michela C, Morris Michael A, Morabia Alfredo

Abstract excerpt

BACKGROUND: There is currently no evidence about the genetic bases of postoperative pain variability in children. METHODS: We prospectively followed a cohort of 168 children after orthopedic or abdominal surgery, who were under morphine patient-controlled analgesia. The children and their parents were genotyped for 6 candidate-gene polymorphisms (single-nucleotide polymorphisms [SNPs]) implicated in nociception...

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Source

Identifiers

PMID: 23223113
DOI: 10.1213/ANE.0b013e31826f0637

Genes

ABCB1
COMT
NTRK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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