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Article

Skin barrier integrity and natural moisturising factor levels after cumulative dermal exposure to alkaline agents in atopic dermatitis.

Acta dermato-venereologica - 1 Nov 2014

Angelova-Fischer Irena, Dapic Irena, Hoek Anne-Karin, Jakasa Ivone, Fischer Tobias W, Zillikens Detlef, Kezic Sanja

Abstract excerpt

Dermal exposure to alkaline agents may lead to skin barrier damage and irritant contact dermatitis. The objective of this study was to investigate the effects of cumulative exposure to 0.5% sodium lauryl sulphate (SLS) and 0.15% NaOH on the barrier function and natural moisturising factor (NMF) levels in atopic dermatitis and healthy volunteers with known filaggrin genotype. The skin response was monitored by...

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Identifiers

PMID: 24531413
DOI: 10.2340/00015555-1815

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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