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Article

Pro-inflammatory interleukin-1 genotypes potentiate the risk of coronary artery disease and cardiovascular events mediated by oxidized phospholipids and lipoprotein(a).

Journal of the American College of Cardiology - 6 May 2014

Tsimikas Sotirios, Duff Gordon W, Berger Peter B, Rogus John, Huttner Kenneth, Clopton Paul, Brilakis Emmanuel, Kornman Kenneth S, Witztum Joseph L

Abstract excerpt

OBJECTIVES: The aim of this study was to assess the influence of pro-inflammatory interleukin (IL)-1 genotype status on the risk for coronary artery disease (CAD), defined as >50% diameter stenosis, and cardiovascular events mediated by oxidized phospholipids (OxPLs) and lipoprotein (Lp) (a). BACKGROUND: OxPLs are pro-inflammatory, circulate on Lp(a), and mediate CAD. Genetic variations in the IL-1 region are...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24530664
DOI: 10.1016/j.jacc.2013.12.030
PMCID: PMC4008715

Genes

CAD

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