The I4399M variant of apolipoprotein(a) is associated with increased oxidized phospholipids on apolipoprotein B-100 particles.

doi:10.1016/j.atherosclerosis.2009.09.077

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Article

The I4399M variant of apolipoprotein(a) is associated with increased oxidized phospholipids on apolipoprotein B-100 particles.

Atherosclerosis - 1 Apr 2010

Arai Kiyohito, Luke May M, Koschinsky Marlys L, Miller Elizabeth R, Pullinger Clive R, Witztum Joseph L, Kane John P, Tsimikas Sotirios

Abstract excerpt

OBJECTIVES: The LPA I4399M (rs3798220) single nucleotide polymorphism (SNP) is associated with increased plasma levels of Lp(a) and advanced coronary artery disease (CAD). We hypothesized that carriers of the Met allele of the I4399M SNP would also have elevated levels of oxidized phospholipids (OxPL) on apoB (OxPL/apoB) particles. METHODS AND RESULTS: Plasma levels of Lp(a) and OxPL/apoB were measured in...

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PMID: 19880117
DOI: 10.1016/j.atherosclerosis.2009.09.077

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