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Article

Interleukin-1 genotypes modulate the long-term effect of lipoprotein(a) on cardiovascular events: The Ioannina Study.

Journal of clinical lipidology - 1 Jan 2000

Naka Katerina K, Bechlioullis Aris, Marini Aikaterini, Sionis Dimitrios, Vakalis Konstantinos, Triantis Georgios, Wilkins Leon, Rogus John, Kornman Kenneth S, Witztum Joseph L, Doucette-Stamm Lynn, Michalis Lampros K, Tsimikas Sotirios

Abstract excerpt

BACKGROUND: Lipoprotein(a) [Lp(a)] is a genetic risk factor for cardiovascular disease (CVD), and proinflammatory interleukin-1 (IL-1) genotypes may influence Lp(a)-mediated CVD events. The genotype IL-1(+) is associated with higher rates of inflammation than IL-1(-) genotype. Targeting IL-1β was recently shown to decrease CVD events independent of low-density lipoprotein-cholesterol levels. OBJECTIVE: The...

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PMID: 29310992
DOI: 10.1016/j.jacl.2017.12.004

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CAD

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